1172500-91-2, 4-Benzenesulfonylpiperidine Hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 4-(phenylsulfonyl)piperidine hydrochloride (l .Og, 3.8 mmol), (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-difluoro-4-hydroxyphenyl)propanoic acid (l .lg, 3.5 mmol), DIPEA (1.8 mL, 10.4 mmol), DCM (16 mL) and DMF (4 mL) was treated with HATU (1.59 g, 4.2 mmol). The mixture was stirred for lh then the resulting solution was allowed to stand for 18 h. The mixture was diluted with dichloro methane (30 mL) and washed with saturated sodium hydrogen carbonate (aq.) (20 mL) then saturated brine (2 x 20 mL). The organic phase was dried (Na2S04) and concentrated in vacuo and purified by chromatography on a Si cartridge eluting with 0-20% DCM in ethyl acetate to give Intermediate 41 A (780 mg). LCMS (Method 3): Rt = 1.25 min. m/z 525.3 [M+H]+
1172500-91-2, The synthetic route of 1172500-91-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CHIESI FARMACEUTICI S.P.A.; ACCETTA, Alessandro; RANCATI, Fabio; CAPELLI, Anna Maria; CLARK, David Edward; TISSELLI, Patrizia; EDWARDS, Christine; CHEGUILLAUME, Arnaud Jean Francois Auguste; BHALAY, Gurdip; (101 pag.)WO2020/16129; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem