With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.221874-51-7,(R)-tert-Butyl (2-oxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.
2-oxo-piperidin-3-yl carbamate (R)-tert-butyl (642 mg, 3.00 mmol) N, sodium hydride at room temperature to N- dimethylformamide (3 mL) solution of (132mg, 3.3 mmol) It was added. The reaction mixture was stirred for 30 minutes, iodomethane (206muL, 3.3 mmol) was added and stirring was continued for 1 hour. The reaction mixture was poured into water (50 mL), using the continuous extraction apparatus overnight, and extracted with EtOAc (100mL). The organic extract was evaporated to dryness under vacuum, the residue of the crude SiO2 chromatography (23g, CH2Cl2 / MeOH / NH4OH, 100: 0: 0 ~ 94: 5.7: 0.3) was purified by on, to give 1-methyl-2-oxo-piperidin-3-yl carbamic acid (R) -tert- butyl 310mg (45%) as a viscous oil colorless., 221874-51-7
221874-51-7 (R)-tert-Butyl (2-oxopiperidin-3-yl)carbamate 45092193, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; F.HOFFMANN-LA ROCHE AG; HENDRICKS, ROBERT THAN; HERMANN, JOHANNES CORNELIUS; KONDRU, RAMA K; LOU, YAN; LYNCH, STEPHEN M; OWENS, TIMOTHY D; SOTH, MICHAEL; (50 pag.)JP5667692; (2015); B2;,
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