With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140645-24-5,(S)-3-(Aminomethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.
Compound 10a was prepared from compound 8 in 85% yield as a colorless solid, using a similar approach to that described for 9a. 1H NMR (DMSO-d6) delta 1.16-1.85 (5H, m), 1.32 (9H, s), 2.31-2.78 (2H, m), 2.58 (3H, s), 3.15-3.29 (2H, m), 3.60-3.94 (2H, m), 3.80 (3H, s), 6.78 (1H, t, J = 2.1 Hz), 7.54 (1H, t, J = 2.1 Hz), 7.59-7.67 (1H, m), 7.71-7.76 (1H, m), 7.92 (1H, d, J = 3.7 Hz), 9.44 (1H, s); MS (ESI) m/z 514 [M+H]+.
140645-24-5, As the paragraph descriping shows that 140645-24-5 is playing an increasingly important role.
Reference：
Article; Kunikawa, Shigeki; Tanaka, Akira; Mukoyoshi, Koichiro; Nagashima, Shinya; Tominaga, Hiroaki; Chida, Noboru; Tasaki, Mamoru; Shirai, Fumiyuki; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3269 – 3277;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem