With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109384-19-2,tert-Butyl 4-hydroxypiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To the stirred solution of tert- butyl 4-hydroxypiperidine-l-carboxylate (26 g, 130 mmol) in /V, N- dimethyl form amide (100 mL) under nitrogen atmosphere at 0C, sodium hydride (6 g, 149 mmol) was added in portions and reaction mixture was stirred at 0 C for 20 min. 4-fluorobenzonitrile (15 g, 124 mmol) was dissolved in 20 mL of /V,/V-dimethyl form amide and added drop wise at 0 C. The reaction mixture was heated to 25 C and stirred for 16 h, then cooled to 0 C and quenched by adding water (100 mL) drop wise. The product was extracted twice by ethyl acetate (200 mL). The combined ethyl acetate layer was washed with ice cold water (300 mL), dried over anhydrous sodium sulphate and concentrated under reduced pressure to obtain a crude product. The crude product was purified by flash column chromatography using 40% ethyl acetate in hexane as an eluent to obtain tert- butyl 4-(4- cyanophenoxy)piperidine-l-carboxylate (37.2 g, 123 mmol, 99 % yield).
109384-19-2, As the paragraph descriping shows that 109384-19-2 is playing an increasingly important role.
Reference：
Patent; PI INDUSTRIES LTD.; BHUJADE, Paras Raybhan; NAIK, Maruti N; PAWAR, Rajesh; TRIVEDI, Pooja; DENGALE, Rohit Arvind; KULKARNI, Shantanu Ganesh; TEMBHARE, Nitin Ramesh; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; KLAUSENER, Alexander G.M.; (172 pag.)WO2020/70610; (2020); A1;,
Piperidine – Wikipedia
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