With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24686-78-0,1-Benzoylpiperidin-4-one,as a common compound, the synthetic route is as follows.
Step1 : Ethyl5-benzovl-4, 5, 6, 7-tetrahvdrothienor3, 2-clpvridine-2-carboxylate :; To a stirred dry DMF (7.3 g, 100 mmol), POCI3 (12.25 g, 80 mmol) was slowly added between 0°C to 5° C. After the addition the solidified mass was dissolved in CH2CI2 (20 ml) and stirred at room temperature for 2 hrs. Again the temperature was cooled to 0°C and 1-benzoyl-4-piperidone in CH2CI2 was added slowly. After the addition the reaction mixture was stirred at room temperature for 2 hrs and poured over crushed ice and sodium acetate. It was stirred for 30 minutes at room temperature. Extracted with CH2CI2 ; washed well with water; dired over anhydrous MgS04 and concentrated. The crude product was dissolved in CH2CI2 and ethylmercaptoacetae (9.6 g, 80 mmol)/Et3N (10.1 g, 100 mmol) was added slowly at room temperature. The reaction mixture was refluxed for 2 hrs and quenched with water. CH2CI2 layer was washed well with water; dried over anhydrous MgS04 ; filtered and concentrated. The product was purified by Si02 column chromatography by eluting it with 50percent ethylacetae ; hexane. Yellow oil ; Yield : 6.4 gms (25percent); M+H 316., 24686-78-0
The synthetic route of 24686-78-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; WYETH; WO2003/93279; (2003); A1;,
Piperidine – Wikipedia
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