With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.
[0071] To a cooled solution of 2,2,6,6-tetramethylrhoirhoeridine (15ml) in dry THF (100ml), 40ml of n-butyllithium was added drop wise over 10 minutes. The mixture was then cooled to -78C followed by addition of (lR,2S,5R)-2-isorhororhoyl-5-methylcyclohexyl) (1S,2S,5R)- 2-isopropyl-5-methylcyclohexyl succinate (15g) over 10 min and then 2.2 ml of bromochloromethane was added dropwise over a period of 10 min. The mixture was stirred for two hours and then 1.5 ml of isobutyraldehyde was added to quench the unreacted anion and the reaction mixture was then stirred for an additional 30 min. The reaction mixture was poured onto IN HCl and the reaction product was extracted with ether (3xl00ml), washed with brine and then dried. Column chromatography (18:l-hexane-ether) was used to give of (lR,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2- (lS,2S,5R)-2-isopropyl-5- methylcyclohexyl)-cyclopropane-l,2-dicarboxylate in 85% yield.
768-66-1, The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NEUROMED PHARMACEUTICALS LTD.; WO2008/43183; (2008); A1;,
Piperidine – Wikipedia
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