With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.
Reference Example 6 4-Methylamino-1-(phenylmethyl)piperidine (Reference compound No. 6-1) A solution of 1-phenylmethyl-4-piperidone (20.0 g) and methylamine hydrochloride (35.7 g) in isopropanol (270 ml) is cooled with ice. A solution of sodium methoxide (28.5 g) in methanol (120 ml) is added dropwise thereto, and the mixture is stirred for two hours. Then, sodium hydroxide (7.00 g) is added thereto, temperature is raised to room temperature, and the whole is stirred for one hour. The reaction mixture is cooled with ice again, sodium borohydride (5.40 g) is added thereto, and the whole is stirred for 1.5 hours. Insoluble matters are filtered out, and the filtrate is concentrated under reduced pressure. Water is added to the residue, and the whole is extracted with diethyl ether. The extract is washed with saturated brine and dried over anhydrous magnesium sulfate. The extract is concentrated under reduced pressure to give 11.8 g of the titled compound as an oily matter. IR(Film,cm-1): 3284,2936,2796,1994,791,739., 3612-20-2
As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.
Reference：
Patent; Santen Pharmaceutical Co., Ltd.; US6410576; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem