With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-06-8,tert-Butyl 3-amino-3-methylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
A solution of tert-butyl 3-amino-3-methylpiperidine-l-carboxylate (0.1091 g, 0.5091 mmol) and TEA (0.1419 mL, 1.018 mmol) in DCM (5.1 mL) was treated with acetic anhydride (72.05 mu, 0.7636 mmol). The reaction was monitored for completion by TLC (EtOAc/ silica, using ninhydrin stain). Upon completion, the reaction mixture was diluted with DCM (40 mL) and washed with brine (3 x 20 mL). The organic extracts were dried over anhydrous MgS04(S), filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography using DCM as eluent to afford title compound (0.104 g, 80% yield). MS (apci) m/z = 157.2 (M+H-Boc).
1158759-06-8, The synthetic route of 1158759-06-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ANDREWS, Steven W.; BLAKE, James F.; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MORENO, David A.; REN, Li; WALLS, Shane M.; (421 pag.)WO2018/136661; (2018); A1;,
Piperidine – Wikipedia
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