With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.180307-56-6,tert-Butyl 4-vinylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To the mixture of Zn (4.64 g, 70.99 mmol) in dioxane (50 mL) under N 2 atmosphere was added tert-butyl 4-vinylpiperidine-1-carboxylate (5.0 g, 23.66 mmol) at 20C. Then CCl 3COCl (6.45 g, 35.49 mmol) was added at 20C. The mixture was stirred at 20C for 12 hours. To the reaction mixture was added aq. NaHCO 3 (50 mL) at 0C. Then the mixture was extracted with EA (50 mL5) and the combine organic phase was dried over anhydrous Na 2SO 4 and concentrated. The residue was purified by column chromatography (SiO 2, PE/EA = 50/1 to 20/1). Tert-butyl 4- (2, 2-dichloro-3-oxocyclobutyl) piperidine-1-carboxylate (3.0 g) was obtained. 1H NMR (400 MHz, CDCl 3) delta ppm: 4.05 -4.21 (m, 2 H) 3.04 -3.27 (m, 2 H) 2.77 (br, 2 H) 2.60 (q, J = 10.4 Hz, 1H) 2.03 -2.10 (m, 1H) 1.84 -1.97 (m, 1H) 1.52 -1.63 (m, 1H) 1.46 (s, 9 H) 1.16 -1.41 (m, 3 H)., 180307-56-6
As the paragraph descriping shows that 180307-56-6 is playing an increasingly important role.
Reference：
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem