4629-78-1, 3-Methylpiperidin-4-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
methyl 6-r(1-methylethyl)sulfonyll-3-r(3-methyl-4-oxo-1-piperidinyl)methyll-2-r3- (trifluoromethyl)phenyll-4-quinolinecarboxylateA suspension of methyl 3-methyl-6-[(1-methylethyl)sulfonyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate (1.25 g, 2.77 mmol), V-bromosuccinimide (0.641 g, 3.60 mmol), and benzoyl peroxide (0.067 g, 0.277 mmol) in carbon tetrachloride (27 ml) was heated to 100C for 19 h. The mixture was cooled to room temperature, and the solvent was removed under reduced pressure. The residue was suspended in acetonitrile (20 mL), and 3-methyl-piperidin-4-one hydrochloride (0.497 g, 3.32 mmol) and A/, V-diisopropylethylamine (1.209 mL, 6.92 mmol) were added. The mixture was stirred at room temperature for 22 h. The solvent was removed under reduced pressure, and the residue was diluted with 10% Na2C03. The aqueous mixture was extracted with ethyl acetate (2 x 25 mL). The combined organic extracts were dried over Na2S04, filtered, and concentrated in vacuo. The crude residue was loaded onto florisil and purified using silica gel chromatography (ISCO, 12 g silica, 5-40% ethyl acetate/hexanes, 12 g silica) to afford methyl 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3- (trifluoromethyl)phenyl]-4-quinolinecarboxylate (1.24 g, 76% yield). 1H NMR (400 MHz, DMSO- d6) 58.35 – 8.41 (m, 2H), 8.22 (dd, J = 2.01 , 8.81 Hz, 1 H), 8.03 (s, 1 H), 7.93 (t, J = 8.94 Hz, 2H), 7.75 – 7.82 (m, 1 H), 4.08 (s, 3H), 3.82 (s, 2H), 3.65 (quin, J = 6.74 Hz, 1 H), 2.87 (dd, J = 5.04, 10.07 Hz, 2H), 2.22 – 2.47 (m, 3H), 2.06 (d, J = 13.60 Hz, 1 H), 1.92 – 2.01 (m, 1 H), 1.23 (s, 3H), 1.21 (s, 3H), 0.77 (d, J = 6.55 Hz, 3H); MS (m/z) 563.1 (M+H+)., 4629-78-1
The synthetic route of 4629-78-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M.; HILFIKER, Mark, A.; MANAS, Eric, S.; YE, Guosen; WO2011/119701; (2011); A1;,
Piperidine – Wikipedia
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