109384-19-2, tert-Butyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation Example 1 (4-(4-(trifluoromethoxy)phenoxy)piperidine (I-6a) P-trifluoromethoxy phenol (32.7 g, 184 mmol), N-Boc-4-hydroxy piperidine (37 g, 184 mmol) and triphenylphosphine (48.3 g, 184 mmol) were dissolved in dry THF (500 mL), DIAD (37.2 g, 184 mmol) was added dropwise while cooling in ice-bath, followed by stirring overnight at room termperature. THF were spun out, residuals were extracted by petroleum ether, extracting solution was concentrated to give 71.2 g light yellow oily matter, crude product yield was more than 100%, directly put into the next reaction step. The crude products obtained from the previous step (66.5 g, 184 mmol) were dissolved in TFA (500 mL), stirring at room temperature. After 3 h, TFA were spun out, add water to residuals, use NaOH solution to adjust pH to above pH 10, extract by ethyl acetate, extracting solution was concentrated followed by column chromatography to give 35.3 g white solid, yield was 73%. ESI-LR: 262.1 [M+1]+.
109384-19-2, 109384-19-2 tert-Butyl 4-hydroxypiperidine-1-carboxylate 643502, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Wang, Tiancai; Xin, Ting; Fan, Houxing; Chen, Yilang; US2013/143864; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem