25137-01-3, (R)-Ethyl piperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step E. Ethyl (3JR)-l-[(2-cyclopentyl-2,3,4,5-tetrahydro-lH-pyrido[4,3-6]indol-8- yl)carbonyl]piperidine-3-carboxylateHATU (1.9 g, 5.0 mmol) and ethyl (3?)-piperidine-3-carboxylate (0.67 g, 4.2 mmol) were added to a solution of cyclopentyl-2,3,4,5-tetrahydro-lH-pyrido[4,3-?]indole-8- carboxylic acid (1.1 g, 3.8 mmol) and DIPEA (1.7 niL, 9.6 mmol) in DMF (25 mL). The reaction mixture was stirred for 2 hrs. and was then concentrated. The product was purified by normal-phase MPLC using 2% Et3N, 5% MeOH and 10% acetone in DCM to provide the title compound as colorless oil (1.6 g, 97 %). 1H NMR (400 MHz, CD3OD) ? 1.27 – 1.38 (m, 3 H)3 1.47 – 1.70 (m, 6 H), 1.70 – 1.87 (m, 5 H), 1.94 – 2.18 (m, 3 H), 2.85 – 3.07 (m, 6 H), 3.16 – 3.53 (m, 2 H), 3.75 – 3.88 (m, 2 H), 4.00 – 4.22 (m, 2 H), 7.12 (dd, J=8.30, 1.46 Hz, 1 H), 7.33 (dd, J=8.40, 0.59 Hz, 1 H), 7.48 (s, 1 H); MS (ESI) (M+H)+ 424.0.
25137-01-3, The synthetic route of 25137-01-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; ASTRAZENECA AB; WO2008/36021; (2008); A1;,
Piperidine – Wikipedia
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