With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159635-49-1,tert-Butyl 4-methylenepiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of tert-butyl 4-methylenepiperidine-1-carboxylate (APOLLO, 10 g, 50. 7 mmol) in dioxane (130 mL) at 0 ¡ãC, a solution of HCI 4M in dioxane (ALFA-AESAR, 130mL, 507 mmol, 10 eq) was added and the mixture was stirred at rt overnight. Monitoring by UPLC and TLC showed the reaction was completed. The solvent was removed under vacuum to afford the desired compound 4-methylidenepiperidine hydrochloride which was used in the next step without further purification (7.6 g, 100percent).1H NMR (400MHz, DMSO-cfe) delta ppm: 9.19 (br s, 2H), 4.86 (s, 2H), 3.06 (t, J = 6.0 Hz, 4H), 2.41 (t, J = 6.0 Hz, 4H)., 159635-49-1
As the paragraph descriping shows that 159635-49-1 is playing an increasingly important role.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BIOVERSYS AG; PORRAS DE FRANCISCO, Esther; REMUINAN-BLANCO, Modesto Jesus; BOUROTTE, Marilyne; DEPREZ, Benoit; WILLAND, Nicolas; (43 pag.)WO2019/34700; (2019); A1;,
Piperidine – Wikipedia
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