With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245648-32-1,tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 2-(benzo[djthiazol-2-yl)acetonitrile (300 mg, 1.72 mmol) in ethanol (10 mL) was added tert-butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate (460 mg, 1.72 mmol), elemental sulfur (55 mg, 1.72 mmol) and morpholine (150 mg, 1.72 mmol) at room temperature and the resulting reaction mixture was heated to reflux at 85 °C for 4 h and monitored by TLC. The reaction mixture was dried under vacuum pressure and the crude compound was purified by trituration with methanol to afford the mixture of the title compounds as an off white solid (700 mg, yield 89percent). LCMS: [M+Hj = 456.0; R = 3.50 mm, [M+Hj = 455.9; R = 3.59 mm., 1245648-32-1
The synthetic route of 1245648-32-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SYROS PHARMACEUTICALS, INC.; ROBERTS, Christopher; ZHANG, Yi; BEAUMIER, Francis; LEPISSIER, Luce; MARINEAU, Jason, J.; RAHL, Peter, B.; SPROTT, Kevin; CIBLAT, Stephane; SOW, Boubacar; LAROUCHE-GAUTHIER, Robin; BERSTLER, Lauren; (469 pag.)WO2016/197078; (2016); A1;,
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