With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-31-4,1-Benzylpiperidine-4-carbonitrile,as a common compound, the synthetic route is as follows.
62718-31-4, Step a: To a solution of N,N-diisopropylamine(14.0 mE, 97.5 mmol) in THF (100 mE) was added (at -78 C. and under N2) n-butyllithium (1.6 M in hexane; 59.0 mE, 94.25 mmol) dropwise. The resulting mixture was stirred for30 mm at RT. 1-benzyl piperidine-4-carbonitrile (6.5 g, 32.5 mmol) in THF (50 mE) was added at -78 C. After stirring for 30 mm at this temperature, n-propyl iodide (20.5 mE, 211.3 mmol) was added. The resulting mixture was stirred at-78 C. for 1 h. The mixture was quenched by addition of saturated aqueous ammonium chloride solution and it was extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2504, filtered and concentrated to obtain 1 -benzyl-4-propylpiperidine-4-carbonitrile (6.0 g, 24.8 mmol). This compound was used without further purification. MS mlz 243 (M+H).
62718-31-4 1-Benzylpiperidine-4-carbonitrile 793383, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem