With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.710972-40-0,tert-Butyl 4-((2-methoxyethyl)amino)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a suspension mixture of 3-oxo-3,4-dihydro-2/-/-pyrido[3,2-jb][1 ,4]thiazine-6- carboxylic acid (60 mg, 0.28 mmol) in DCM (3 mL) were added oxayl chloride (0.13 mL, 1.4 mmol) and the catalytic amount of DMF. After 2.5 h at 25 0C, the mixture was concentrated to provide a brown residue which was re-dissolved in anhydrous DCM (1 mL). The solution was treated with a solution of 1 ,1 -dimethylethyl 4-{[2- (methyloxy)ethyl]amino}-1 -piperidinecarboxylate (80 mg, 0.25 mmol) with triethylamine (0.08 mL, 0.25 mmol). After stirred at 25 0C for 12 hr, the mixture was partitioned between DCM and the aqueous solution of Na2CO3. The aqueous phase was extracted several times with DCM. The organic fractions were combined, concentrated and purified with column chromatography (silica, 0-10% MeOH in DCM) to generate the title compound as an off-white solid (100 mg, 71%): LC/MS (ES) m/e 451 (M+H)+
710972-40-0, The synthetic route of 710972-40-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GLAXO GROUP LIMITED; WO2007/16610; (2007); A2;,
Piperidine – Wikipedia
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