With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3518-83-0,N-Ethyl-4-hydroxypiperidine,as a common compound, the synthetic route is as follows.
Add to the reaction flask1-ethylpiperidin-4-ol (1.0 g, 7.7 mmol), 2,5-dibromopyridine (2 g, 8.5 mmol)And dimethylsulfoxide (30 mL) were added sodium tert-butoxide (1.7 g, 15.4 mmol).The mixture was stirred at room temperature for 3 hours, water (30 mL) was added,Dichloromethane extraction (20 mL x 3) .The organic layers were combined,Washed with saturated brine (20 mL), dried over anhydrous sodium sulfate and the filtrate was concentrated in vacuo.The resulting residue was purified by column chromatography (DCM / MeOH = 10: 1)To give the title compound (702 mg, black solid) in 32% yield., 3518-83-0
As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.
Reference：
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem