With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5810-56-0,4-Acetamidopiperidine,as a common compound, the synthetic route is as follows.
20.1 c lambda/-(1-{4-[2-(4-Benzyloxy-6-oxo-6/-/-pyrimidin-1-yl)-ethyl]-benzyl}-piperidin-4-yl)- acetamideTo 100 mg (0.25 mmol) 6-benzyloxy-3-[2-(4-bromomethyl-phenyl)-ethyl]-3H-pyrimidin-4-one (example 20.1 b) in 1.0 mL DCM is added 71 mg (0.50 mmol) lambda/-piperidin-4-yl-acetamide atRT. The reaction mixture is refluxed for 2 h and the solvent is evaporated. The residue is dissolved in DMF and a few drops of formic acid and is transferred to a reverse HPLC for purification (Waters symmetry, C 18; water (0.15 % formic acid)/acetonitrile 95:5 to 5:95).Yield: 75 mg (65% of theory) ESI Mass spectrum: [M+H]+ = 461Retention time HPLC: 2.2 min (method G).
5810-56-0, 5810-56-0 4-Acetamidopiperidine 1445156, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/22979; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem