The synthetic route of 710972-40-0 has been constantly updated, and we look forward to future research findings.
710972-40-0, tert-Butyl 4-((2-methoxyethyl)amino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
710972-40-0, 137 N-(l-[2-(lH-Indazol-4-ylV4-mophiholin-4-yl-thienor3,2-d1pyrimidin-6- ylmethvH-piperidin-4-vU-N-(2-methoxy-ethyl)-methanesulfonarnide. EPO Via N- [ 1 -(2-chloro-4-mophiholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)- piperidin-4-yl]-N-(2-methoxy-ethyl)-methanesulfonamide, prepared from N-(2- methoxy-ethyl)-N-piperidin-4-yl-methanesulfonamide.Amine preparation: To a solution of 4-(2-methoxyethylamine)-piperidine-l- carboxylic acid tert-butyl ester (see preparation of 121) (0.50g) in DCM (1OmL) was added triethylamine (0.3OmL) followed by methanesulfonyl chloride (0.16mL). After stirring for 4 h the reaction mixture was then diluted with DCM, washed with sodium bicarbonate solution, dried (MgSO4) and the solvent removed in vacuo. The residue was purified by flash chromatography to yield 4-[methanesulfonyl-(2-methoxy- ethyl)-amino]-piperidine-l -carboxylic acid tert-bxxy ester (0.474g). Treatment of this compound with HCl in DCM/MeOH yielded the desired amine, which was isolated as the hydrochloride salt.1H NMR (400MHz, CDCl3) 1.78 (2H, m), 1.92 (2H, m), 2.21 (2H, t, J=10.9Hz), 2.90 (3H, s), 3.07 (2H, br d, J=I 1.6Hz), 3.38 (5H, m), 3.54 (2H, t, J=6.3Hz), 3.68 (IH, m), 8.83 (2H, s), 3.94 (4H, m), 4.10 (4H, m), 7.38 (IH, s), 7.50 (IH, t,J=7.7Hz), 7.60 (IH, d, J=8.2Hz), 8.29 (IH, d, J=7.1Hz), 9.02 (IH, s), 10.10(1H, br s); MS (ESI+) 586 (MH+).
The synthetic route of 710972-40-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem