15883-20-2, N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 7 A clean and dry four neck round bottom flask was charged with N-((R)-1- phenylethyl)phthalamic acid (28.9 gm), isopropanol (300 ml) and 2′,6′-pipecoloxylidide (25 gm). The reaction mixture was stirred at 25C to 30C for one hour. The reaction mass was cooled to 1 0C to 15C to get a precipitate of corresponding (R)-(-)- 2′, 6′- pipecoloxylidide-phthalamic acid salt (27.30 gm) which was separated by filtration to afford white crystalline solid. IR:- 3300.8, 3032.8, 1677.2, 1629.7, 1583.4, 1529.8, 1444.7, 1378.4, 1244.8, 1037.7, 947.9, 835.5, 699.9 CM”1 NMR:- delta = 1.39(d, J= 4.0Hz, 3H), 1.50-1.70(m, 4H), 2.13(s, 7H), 2.82(dd, J= 2.8Hz, 5.8Hz, 16.4Hz, 1H), 3.13(d, J = 12.4Hz, 1H), 3.79(dd, J = 2.8Hz, 2.8Hz, 1 1.0Hz, 1H), 5.06(pen, 1H), 7.04-7.10(m, 3H), 7.21(t, J= 7.2Hz, 7.2Hz, 1H), 7.3 l(t, J= 7.6Hz, 7.6Hz, 2H), 7.30-7.43(m, 4H), 7.57(d, J= 6.4Hz, 2H), 9.68(s, 1H), 10.27(s, 1H). The filtrate was concentrated under vacuum, treated with 10%) sodium carbonate (500 ml) and stirred the reaction mass at room temperature for 1.5 hours to get a solid. The solid was collected by filtration, washed with water and dried to get (S)-2′,6′-pipecoloxylidide. Yield – 12 gm (96%) Enantiomeric purity – 96.66% (R)-(-)-2′,6′-pipecoloxylidide-phthalamic acid salt was hydro lyzed with 10% sodium carbonate (520 ml) and stirred the reaction mass at room temperature for one hour to get a solid. The solid washed with water and dried to get (R)-2′,6′-pipecoloxylidide. Yield – 9.3 gm (74.4%) Enantiomeric purity – 95.95%
15883-20-2, As the paragraph descriping shows that 15883-20-2 is playing an increasingly important role.
Reference£º
Patent; NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan; WO2014/9964; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem