175213-46-4, N-Boc-Piperidin-4-yl-acetic acid methyl ester is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a -78 C. solution of 2-bromopyridine (1.86 ml, 19.5 mmol) in anhydrous THF (30 ml) was slowly added 1.6 M BuLi soln. in hexanes (10.8 ml, 17.3 mmol), resulting in a dark orange solution. The reaction mixture was allowed to stir for 90 min. at -78 C. The cold reaction mixture was cannulated over a period of 2 h into a -78 C. solution of 76 (2.5 g (9.72 mmol) in anhydrous THF (20 ml). The reaction mixture was allowed to stir for 2.5 h at -78 C., then was allowed to reach rt. The reaction mixture was quenched with AcOH, followed by extraction with CH2Cl2 (3¡Á70 ml). The organic layer was dried over Na2SO4, followed by concentration and flash chromatography (from 50% hexanes/CH2Cl2 to 10% acetone/CH2Cl2) to afford 0.41 g (2.83 g; 14%) of 77 as a yellow oil
175213-46-4, The synthetic route of 175213-46-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Schering Corporation; US2007/10513; (2007); A1;,
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