1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (150 mg, 0.787 mmol) was dissolved in dichloromethane (4 mL) and triethylamine (0.219 mL, 1.573 mmol), and 2-chloro-4-(trifluoromethyl)benzenesulfonyl chloride (241 mg, 0.865 mmol) was added. After stirring for 18 h, the reaction mixture was concentrated in vacuo. The resulting residue was purified by MDAP to give 7-{[2-chloro-4-(trifluoromethyl)- phenyl]sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (38.2 mg, 0.094 mmol, 12% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .37 – 1 .64 (m, 3 H) 1.65 – 1 .75 (m, 1 H) 1.84 – 2.02 (m, 2 H) 2.72 – 2.83 (m, 2 H) 3.09 – 3.18 (m, J=7.78, 7.51 Hz, 2 H) 3.40 (d, J=12.1 1 Hz, 1 H) 3.72 (d, J=12.93 Hz, 1 H) 7.74 (s, 1 H) 7.93 (d, J=9.54 Hz, 1 H) 8.18 (d, J=7.45 Hz, 2 H). MS ES+ve m/z 397 (M+H)., 1187173-43-8
1187173-43-8 2,7-Diazaspiro[4.5]decan-1-one hydrochloride 45074126, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
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