143900-44-1, (S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 57[0363] Synthesis of (^)-l-(3-(7H-pyrrolo[2,3-J]pyrirnidin-4-yloxy)piperidin- chloro-5-fluorophenylamino)ethanone.Reagents and conditions: a) NaH, DMSO, 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H- pyrrolo[2,3-J]pyrimidine; b) TBAF, THF, reflux, 5 h; c) HC1 in 1 ,4-dioxane, rt, 30 min; d) EDCI, HOBt, 2-(3-chloro-5-fluorophenylamino)acetic acid, DMF, rt, 24 h.[0364] Synthesis of (S^-tert-butyl 3-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H- pyrrolo[2,3-J]pyrimidin-4-yloxy)piperidine-l-carboxylate: To a solution of (^-ieri-butyl 3- hydroxypiperidine-l-carboxylate (0.4 g, 2.0 mmol) in DMSO (5 mL) under nitrogen, was added NaH (60% suspension in mineral oil, 79 mg, 2.0 mmol). After the reaction was stirred for 1.5 h at rt, a solution of 4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-J]pyrimidine (564 mg, 2.0 mmol) in DMSO (5 mL) was added dropwise at rt and the mixture was heated at 50 C for 2h. The reaction mixture was cooled to rt, diluted with water (10 mL) and extracted with EtOAc (4 x 60 mL). The combined organic layer was washed with water (50 mL), dried over Na2S04 and concentrated in vacuo to give the crude compound which was purified by column chromatography (silica gel, gradient EtOAc in Hexanes) to give (750 mg, 85%) of the titled intermediate., 143900-44-1
As the paragraph descriping shows that 143900-44-1 is playing an increasingly important role.
Reference£º
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; SCOTT, Daniel; CONLON, Patrick; JENKINS, Tracy, J.; POWELL, Noel; GUAN, Bing; CURERVO, Julio, H.; WANG, Deping; TAVERAS, Art; WO2012/58645; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem