With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220223-46-1,Methyl N-Boc-3-Oxopiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.
General procedure: A solution of Intermediate 55b (0.79 g, 2.9 mmol) and benzyl bromide (0.40 mL,3.4 mmol) in N,N-dimethylacetamide (5 mL) is treated with powdered potassium carbonate (0.5 g, 3.6 mmol) and the mixture is stirred at 65 C overnight. The mixture is cooled, filtered, and concentrated in vacuo. Purification of the crude material by flash chromatography (hexanes/ethyl acetate gradient) affords 1-tert-butyl 3-ethyl 3-benzyl-4-oxopiperidine-1,3-dicarboxylate 55c as a clear oil.
220223-46-1, The synthetic route of 220223-46-1 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Azimioara, Mihai; Alper, Phil; Cow, Christopher; Mutnick, Daniel; Nikulin, Victor; Lelais, Gerald; Mecom, John; McNeill, Matthew; Michellys, Pierre-Yves; Wang, Zhiliang; Reding, Esther; Paliotti, Michael; Li, Jing; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Zimmerman, Matthew; Groessl, Todd; Tuntland, Tove; Joseph, Sean B.; McNamara, Peter; Seidel, H. Martin; Epple, Robert; Bioorganic and Medicinal Chemistry Letters; vol. 24; 23; (2014); p. 5478 – 5483;,
Piperidine – Wikipedia
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