As the paragraph descriping shows that 73579-08-5 is playing an increasingly important role.
With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73579-08-5,1-Methyl-4-(methylamino)piperidine,as a common compound, the synthetic route is as follows.
To E10 (1.04 g, 3.2 mmol) dissolved in THF (40 mL) was added a solution ofN-methyl-4- (methyl-amino)-piperidine (0.5 mL, 3.2 mmol) in THF (2 mL) followed by addition of NaOH (1.3 mL, 2.5 N, 3.2 mmol) and 3.5 mL of water. The reaction mixture stirred and heated at reflux for 2 hours. The reaction mixture was extracted 3 times using dichloromethane ; the combined organic layers were washed with brine and dried over potassium carbonate. The sample was filtered, concentrated, and the resulting solid was dried overnight under vacuum. Column chromatography (90: 9: 1 v: v: v dichloromethane: methanol: ammonium hydroxide) yielded a light yellow solid (Ell) (164 mg,13percent) ; mp94 C ; HPLC : Inertsil ODS 3VC18, 40 : 30: 30[KH2PO4 (0.01 M, pH 3.2) :CH30H : CH3CN], 264 nm, Rt 3.2 min, 96.7percent purity; MS (TOF ES+) m/z 402.1(M+H, 100),231(41. 5), 202.1 (6)., 73579-08-5
As the paragraph descriping shows that 73579-08-5 is playing an increasingly important role.
Reference£º
Patent; REDDY US THERAPEUTICS, INC.; WO2004/26844; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem