Brief introduction of 140645-24-5

140645-24-5, As the paragraph descriping shows that 140645-24-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.140645-24-5,(S)-3-(Aminomethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.

a) l,l-Dimethylethyl (3iS)-3-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-l- piperidinecarboxylateTo a solution of 1,1-dimethylethyl (3.S)-3-(aminomethyl)-l- piperidinecarboxylate (2.0 g, 9.33 mmol) in DCM (12 ml) at 0 0C were added triethylamine (1.7 ml, 12.1 mmol) followed by N-(benzyloxycarbonyloxy)succinimide (2.56 g, 10.3 mmol). After a few minutes the cooling bath was removed and the reaction was stirred at room temperature for 2h. The reaction was diluted with ethyl acetate and washed with water (2x), IN HCl, saturated aq. NaHCO3, brine, dried (Na2SO4) and concentrated. The product was purified on silica gel eluting with 10% ethyl acetate-DCM to give 3.48g of material containing a small amount of N-(benzyloxycarbonyloxy)succinimide which was used directly in next step. LC/MS (ES) m/e 349 (M+H)+.

140645-24-5, As the paragraph descriping shows that 140645-24-5 is playing an increasingly important role.

Reference：
Patent; GLAXO GROUP LIMITED; WO2007/71936; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem