With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.
[396] To a solution of tert-butyl 2-oxopiperidine-l-carboxylate (8.22 g, 41.3 mmol) in anhydrous THF (80 mL) was added LiHMDS (1.0 M in THF, 103 mL, 103 mmol) dropwise under nitrogen atmosphere at -78 C. The reaction mixture was stirred for 20 min and 3-bromoprop-l-ene (10.7 mL, 124 mmol) was added. The resulting mixture was stirred for 15 min, allowed to warm to rt, quenched with water (15 mL), and concentrated in vacuo. The residue was added water (30 mL) and extracted with EtOAc (50 mL x 3). The combined organic phases were washed with brine (50 mL), dried over anhydrous Na2SO i, concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/50) to give the title compound as yellow oil (3.95 g, 35%). MS (ESI, pos. ion) m z: 224.2 [(M-C4H8)+H]+; NMR (600 MHz, CDCI3): delta (ppm) 5.72 (ddt, .7=16.5, 10.5, 7.0 Hz, 2H), 5.06 (d, J= 10.5 Hz, 2H), 5.03 (d, J= 16.5 Hz, 2H), 3.55 (t, J= 5.8 Hz, 2H), 2.46 (dd, J= 13.6, 7.0 Hz, 2H), 2.21 (dd, J= 13.6, 7.0 Hz, 2H), 1.75 (m, 4H), 1.48 (s, 9H).
85908-96-9, As the paragraph descriping shows that 85908-96-9 is playing an increasingly important role.
Reference：
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Minxiong; HU, Haiyang; WANG, Tingjin; WO2015/94803; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem