929252-65-3, tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,929252-65-3
Step 1: preparation of tert-butyl 4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl) aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-methoxyl-7-quinolyl] oxymethyl]piperidine-1-carboxylate: a mixture of intermediate C (1.5 g or 3.0 mmol), intermediate D (1.7 g or 7.6 mmol), DIPEA (1.55 g or 12.0 mmol), HATU (2.3 g or 6.0 mmol), DMAP (0.183 g or 1.5 mmol) in DMF (60 mL) is stirred at 30-40 C overnight. The mixture is concentrated under reduced presure, and the residue is purified by column chromatography (eluent: 1-5% MeOH in DCM) to obtain 1.9 g target compound (yield: 90%). The analytical data of the obtained product are as follows: mass spectrum m/z: 703.30 [M+H].
The synthetic route of 929252-65-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Beijing Konruns Pharmaceutical Co., Ltd.; YUN, Ziwei; WANG, Hongtao; EP2669289; (2013); A1;,
Piperidine – Wikipedia
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