With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.851956-01-9,(S)-Piperidine-3-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.
851956-01-9, A suspension of sodium borohydride (7.6 g; 200 mmol) and (S)-NPA hydrochloride(16.6 g; 100 mmol, from EXAMPLE 2) in THF (100 mL) was heated for 2 h at 700C, tillthe gas evolution ceased. The temperature was lowered to 50C and a solution of concentrated sulfuric acid (10.0 g; 100 mmol) in 40 mL of THFwas added during 30 mm. The suspension was heated to 70C for 1 h, then cooled to room temperature and carefully poured onto 20 g of cracked ice and 20 g of concentrated hydrochloric acid.The mixture was stirred overnight, basified with sodium hydroxide (40% solution in water) to pH >12, filtered and extracted three times with iso-butanol/toluene (9:11; 50 mL). Concentration under reduced pressured yielded (S)-PPM as a solid (47% yield), which had a chemical purity of 96% and an optical purity of 99.64 : 0.36.
As the paragraph descriping shows that 851956-01-9 is playing an increasingly important role.
Reference：
Patent; REUTER CHEMISCHE APPARATEBAU KG; REUTER, Karl; WEDEL, Tobias; ANDRUSHKO, Vasyl; WIEGAND, Christian; STOLZ, Florian; WO2014/173855; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem