With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3040-44-6,1-(2-Hydroxyethyl)piperidine,as a common compound, the synthetic route is as follows.
A mixture of 20 mg of 2-(4-bromophenyl)-l,3-benzoxazole-5-carbonitrile (INTERMEDIATE 7), 17 mg of 2-piperidin-l-ylethanol, and 8 mg of sodium hydride (60% dispersion in oil) in 1 mL of toluene was purged and flushed with argon. Tris(dibenzylideneacetone) dipalladium (3 mg) and racemic BINAP (3 mg) were added and the mixture was heated to 800C and stirred overnight at this temperature. The reaction mixture was cooled and added directly to a 1000-muM thin-layer chromatography plate, eluting with 4% isopropanol in CH2Cl2 to provide 3.4 mg (15%) of the title compound. Mass spectrum (ESI)348.3 (M+l). 1H NMR (500 MHz, CDCl3): delta 8.18 (d, J=8.5 Hz, 2H), 8.02 (s, IH), 7.63 (m, 2H), 7.05 (d,J=9 Hz, 2H), 4.26 (t, J=6 Hz, 2H), 3.48 (d, J=3Hz, IH), 2.88 (br t, J=5.5 Hz, 2H), 2.61 (m, 3H), 1.68 (m, 5H), 1.49 (m, IH)., 3040-44-6
As the paragraph descriping shows that 3040-44-6 is playing an increasingly important role.
Reference£º
Patent; MERCK & CO., INC.; WO2007/70173; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem