With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120014-07-5,2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,as a common compound, the synthetic route is as follows.
Preparation of l-Benzyl-4-[(5, 6-dimethoxy-l-indanon)-2-v? methylpiperidine hydrochloride (Donepezil Hydrochloride) l-Benzyl-4-[5, 6-dimethoxy-l-indanon)-2-ylidenyl] methyl piperidine was taken in tetrahydrofuran (200ml) followed by addition of palladium-carbon (Ig). The mixture was hydrogenated at 20-30 0C under 1,5 atmospheric pressure for 8 hours, monitored by HPLC analysis and analysis shows ~ 38.5% of debenzylated impurity in the reaction mass.
120014-07-5, 120014-07-5 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 10762160, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; WO2007/108011; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem