With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-52-2,1-Boc-4-Cyanopiperidine,as a common compound, the synthetic route is as follows.,91419-52-2
To a mixture of 4-cyano-piperidine-1-carboxylic acid tert-butyl ester (6.3 g, 30 mmol), K2C03 (4.2 g, 30 mmol) in H20 (50 mL) and EtOH (30 mL) was added hydroxylamine hydrogenchloride (4.17 g, 60 mmol). The mixture was heated under reflux overnight, cooled to room temperature and ethanol was removed in vacuo. The residue was extracted with EtOAc (300 mL). The organic layer was washed successively with H20 and brine. After drying (Na2 SO4), the solvent was removed to afford the desired product
91419-52-2 1-Boc-4-Cyanopiperidine 1514443, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; CYMABAY THERAPEUTICS; MCWHERTER, Charles A.; (176 pag.)WO2018/26890; (2018); A1;,
Piperidine – Wikipedia
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