With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.
General procedure: A mixture of compound 8 (0.3 mmol) and corresponding ketones (0.4 mmol) in Ti(OPr)4 was stirred at 70 C for 8 h and cooled to room temperature. MeOH (5 mL) and NaCNBH3 (1.6 mmol) wasadded to the mixture, and stirred for 5 h at 40 C. The mixture was quenched by 1 N NaOH (10 mL), filtered by Celite, and washed by MeOH. The MeOH was evaporated under vacuo. The residue wasdiluted by H2O, and extracted by Et2O. The combined organic layer was washed by brine, dried over anhydrous MgSO4, filtered, andconcentrated. The residue was purified over silica gel column(DCM: MeOH = 30 : 1) to yield oils 11c-g (yield, 40-70%).
236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various.
Reference£º
Article; Lv, Kai; Wang, Apeng; Tao, Zeyu; Fu, Lei; Liu, Hongtao; Wang, Bin; Ma, Chao; Wang, Hongjian; Ma, Xican; Han, Bing; Wang, Auyu; Zhang, Kai; Liu, Mingliang; Lu, Yu; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 208 – 217;,
Piperidine – Wikipedia
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