113310-52-4, 4-(Piperidin-4-yl)aniline is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Substrates NT1-003 (80 mg, 0.32 mmol) and NT1-004 (28.4 mg, 0.32 mmol) were mixed in a microwave tube with EtOH (1 mL). Then 0.1NHC1 (1 mL) was added to the tube. The vessel was sealed and heated to 150 C for 40 minutes. The solvent was removed under reduced pressure, the residue washed with DCM, and filtered to afford 5 -chloro-N2-(4-Q,iperidin-4-yl)phenyl)-1V4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4- diamine (NT1-005) as a peach solid (90 mg, 72.0%), mp 160 C (dec.). HPLC 85.6% [R = 7.51 mm, 30% CH3OH in 0.1% TFA water 20 mm]. ?H NMR (400 MHz, Methanol-d4) oe 7.94 (s,1H), 7.49 (d, J= 8.2 Hz, 2H), 7.35 (d, J= 8.4 Hz, 2H), 4.16 (p, J= 6.2 Hz, 1H), 3.86-3.68 (m,2H), 3.65 -3.46 (m, 4H), 3.22-3.09 (m, 2H), 3.00-2.90 (m, 1H), 2.14- 1.82 (m, 8H), 1.69-1.58(m, 1H). ?3C NMR (101 MHz, Methanol-d4) oe 159.20, 151.43, 141.84, 139.72, 135.04, 127.16,122.99, 105.19, 76.74, 67.63, 45.23, 44.15, 39.15, 29.68, 28.54, 25.01. LC-MS (ESI+) m/z388.18965 (M+H) HRMS (ESI+) m/z calculated for C2oH26ClN5O(M+H)388.1899, found,388.1900.
113310-52-4, 113310-52-4 4-(Piperidin-4-yl)aniline 22047841, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; MAHAJAN, Nupam, P.; MAHAJAN, Kiran, N.; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; WO2015/21149; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem