141699-59-4, tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
tert-butyl 4-(4-iodo-1H-pyrazol-1-yl)piperidine-1-carboxylate (3) NaH (1.2 eq., 0.68 mmol) was added portionwise to a stirred solution of 4-iodopyrazole (0.57 mmol) in DMF (2 L) at 4 C. The resulting mixture was stirred for 1 hour at 4 C. and 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester, compound 2 (1.1 eq., 0.63 mmol) was then added. The resulting mixture was heated to 100 C. for 12 h. The reaction was quenched with H2O and extracted with EtOAc several times. The combined organic layers were dried, filtered, and concentrated to afford an orange oil. The residue was purified by silica gel chromatography (eluting with 5% EtOAc in pentane) to give compound 3 as a white solid (140 g, 66%).
As the paragraph descriping shows that 141699-59-4 is playing an increasingly important role.
Reference£º
Patent; Pfizer Inc.; Christensen, James Gail; Zou, Yahong; (37 pag.)US2016/206608; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem