4606-65-9, 3-(Hydroxymethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A stirred solution of 3-(hydroxymethyl)-1-piperidine (0.500 g, 4.34 mmol, Aldrich) in 20 mL of anhydrous dichloromethane was treated with di-f-butyl dicarbonate (1.04 g, 4.77 mmol) dissolved in 10 mL of anhydrous dichloromethane. After 18 hours the solution was diluted with dichloromethane, washed with 10% aqueous citric acid (2x), saturated aqueous NaHC03 (2x), dried over Na2S04, and concentrated at reduced pressure to give a transparent, viscous oil. The crude material was subjected to flash chromatography (silica gel, hexane/EtOAc) to afford 0.88 g (95%) of f-butyl 3-(hydroxymethyl)-l-piperidinecarboxylate as a white, crystalline solid. 1H NMR (DMSO-cf6): 5 4.48 (t, 1H), 3.96 (brs, 1H), 3.77 (d, 1H), 3.26 (m, 1H), 3.17 (m, 1H), 2.67 (t, 1H), 2.43 (brs, 1H), 1.65 (m, 1H), 1.56 (m, 1H), 1.50-1.33 (m, 10H), 1.26 (m, 1H), 1.06 (m, 1H).
4606-65-9, 4606-65-9 3-(Hydroxymethyl)piperidine 107308, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/20415; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem