With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.548769-02-4,1-(Piperidin-4-yl)pyrrolidin-2-one hydrochloride,as a common compound, the synthetic route is as follows.
548769-02-4, EXAMPLE 23; 1-(1-{2-[4-(Benzothiazol-2-yloxy)-phenoxy]-ethyl}-piperidin-4-yl)-pyrrolidin-2-one; A suspension of 2- [4- (2-BROMO-ETHOXY)-PHENOXY]-BENZOTHIAZOLE (EXAMPLE 9; 200 mg, 0.57 mmol), 1-piperindin-4-yl-pryyolidin-2-one hydrochloride (117 mg, 0.57 MMOL), and SILICYCLEE dimethylamine resin (800 mg, 1. 14 mmol) in CH3CN was heated to 70 C for 18 h. The reaction mixture was filtered, and the collected resin was rinsed with CH3CN. The combined filtrates were concentrated under reduced pressure yielding a crude solid, which was purified on SI02 (10 G ; 0-100% 10% [2 M NH3 in CH3OH] in CH2CI2/CH2CI2) to provide a tacky off-white solid (142 mg, 63% yield). MS (ESI) : mass calculated for C24H27N3O3S, 337.18 ; m/z found, 348. 5 [M+H}+. 1H NMR (400 MHz, CECI3) : 7.85 (dd, J= 8.0, 0.5, 1H), 7.75 (dd, J= 8.0, 0.8, 1H), 7.41 (dt, J=7 3,1. 5, 1H), 7.34-7. 22 (m, 3H), 7.02-6. 92 (m, 2H), 4.15 (br d, J = 48.8, 2H), 3.80-3. 65 (m, 1H), 3.40 (t, J=7. 0, 1H), 3.30-3. 10 (BRS, 1H), 3.15, (q, J= 7.2, 1H), 2.96 (brs, 1H), 2.42, (t, J=7. 9,2H), 2.10-1. 99 (m, 1H), 1.81-1. 70 (m, 1H) 1.68-1. 52 (m, 4H), 1.50 (d, J=6. 5,3H)
The synthetic route of 548769-02-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/12296; (2005); A1;,
Piperidine – Wikipedia
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