91419-52-2, 1-Boc-4-Cyanopiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
91419-52-2, 4-Cyanopiperidine-1-formic acid tert-butyl ester (3.00 g, 14.27 mmol) was dissolved in tetrahydrofuran (30.00 mL), slowly added dropwise with lithium hexamethyldisilazide (1M, 28.54 mL) at -78 C and under nitrogen protection, stirred for 1 hour, slowly added dropwise with ethyl chloroformate (3.10 g, 28.54 mmol), and then stirred under nitrogen protection at -78 C for 1 hour. TLC showed that the reaction was complete. The reaction solution was quenched with a saturated solution of sodium bicarbonate (15 mL), and extracted with ethyl acetate (20 mL x 2), and the combined organic phases were washed with a saturated solution of ammonium chloride (50 mL), dried over anhydrous sodium sulfate (10 g), filtered and concentrated to give 1E. 1H NMR (400MHz, DMSO-d6) delta= 4.23 (q, J = 7.1 Hz, 2H), 4.00 – 3.92 (m, 2H), 2.95 (br, 2H), 2.07 (br d, J = 13.3 Hz, 2H), 1.89 – 1.76 (m, 2H), 1.40 (s, 9H), 1.24 (t, J = 7.1 Hz, 3H).
91419-52-2 1-Boc-4-Cyanopiperidine 1514443, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; Medshine Discovery Inc.; LIU, Xile; DING, Charles Z.; CHEN, Shuhui; WU, Lingyun; HU, Lihong; WAN, Haiwen; (118 pag.)EP3567030; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem