With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21987-29-1,4,4-Difluoropiperidine,as a common compound, the synthetic route is as follows.
Step 8: N-(cis-3-{[(4,4-Difluoropiperidin-1-yl)sulfonyl]methyl}cyclobutyl)-N-methyl-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine To a mixture of 4,4-difluoropiperidine (77 mg, 0.64 mmol) and triethylamine (97 mg, 0.96 mmol) in tetrahydrofuran (20 mL) at 0¡ã C. was added dropwise a solution of cis-[3-(methyl{7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)cyclobutyl]methanesulfonyl chloride (150 mg, 0.320 mmol) in tetrahydrofuran (10 mL). The mixture was allowed to warm to room temperature overnight. The solvent was evaporated and the residue was taken up in ethyl acetate (80 mL). The solution was washed with brine (30 mL), dried over sodium sulfate and concentrated to afford the crude title compound (134 mg) as a white solid. LC/MS (exact mass) calculated for C24H29F2N5O4S2; 553.651. found (M+H+); 554.3., 21987-29-1
As the paragraph descriping shows that 21987-29-1 is playing an increasingly important role.
Reference£º
Patent; Pfizer Inc.; Brown, Matthew Frank; Fenwick, Ashley Edward; Flanagan, Mark Edward; Gonzales, Andrea; Johnson, Timothy Allan; Kaila, Neelu; Mitton-Fry, Mark J.; Strohbach, Joseph Walter; TenBrink, Ruth E.; Trzupek, John David; Unwalla, Rayomand Jal; Vazquez, Michael L.; US2014/243312; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem