With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923036-30-0,N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine,as a common compound, the synthetic route is as follows.
Example 9; Preparation of [(3R, 4R)-1-benEyl-4-methyl-piperidin-3-yl]-methyl-(7H-pyrrolo[2,3-cl]pyrimidin-4-y.)-amine:; To a clean, nitrogen-purged reactor were charged 50% sodium hydroxide solution (210 ml) and (1-benzyl-4-methyl-piperidin-3-yl)-methyl-[7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine (30.0 g, 0.061 mol). The mixture was heated to 95-105C for a minimum of 5 hours then cooled to 70- 900C and water (300 ml) was added. The slurry was cooled to room temperature over a minimum of 1.5 hours and held at room temperature for 1 hour. The solids were isolated by filtration and washed with water (120.0 ml) to obtain 25.2 g of the title compound, water wet.1H NMR (400 MHz, CD3OD): delta 8.05 (s, 1H), 7.36-7.28 (m, 5H)1 7.24-7.20 (m, 1H), 7.06 (d, J=3.7 Hz, 1H), 6.62 (d, J=3.7 Hz, 1H), 5.08 (bs, 1H), 3.58-3.52 (m, 5H), 2.85 (dd, J=11.2, 7.0 Hz, 1H), 2.68 (dd, J=11.2, 3.7 Hz, 1H), 2.65-2.59 (m, 1 H), 2.45-2.39 (m, 1H), 2.29-2.20 (m, 1H), 1.90-1.81 (m, 1 H), 1.70- 1.63 (m, 1 H), 0.98 (d, J=7.0 Hz, 3H). 13C NMR (400 MHz, Of6-DMSO1 mixture of isomers): delta 166.8, 164.4, 158.6, 155.1 , 138.4, 137.9, 137.8, 136.6, 135.5, 135.3, 112.7, 110.0, 72.4, 64.3 (b), 62.4, (b), 60.3 (b), 44.5, 41.8, 40.9, 30.5, 24.8.
923036-30-0, The synthetic route of 923036-30-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PFIZER PRODUCTS INC.; WO2007/12953; (2007); A2;,
Piperidine – Wikipedia
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