With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24228-40-8,Ethyl N-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.,24228-40-8
Step 1. 1-Benzylpiperidine-4-carboxylic acid Ethyl 1-benzylpiperidine-4-carboxylate (13.73 g) in methanol (100 ml) was treated with 40% aqueous sodium hydroxide (8.3 ml) at room temperature 16 h. The solvent was removed in vacuo and the residue re-dissolved in water (100 ml), acidified with dilute hydrochloric acid to pH 4 and concentrated. The residue was extracted with hot ethanol (200 ml), filtered and concentrated again. Addition of dichloromethane resulted in crystallization giving the title compound as a colourless crystaline solid, (3.24 g, 27%). Removal of solvent from the filtrate and trituration with ether gave a second batch as an amorphous white solid, (9.24 g, 73%); numax (CH2 Cl2) 2496 (vbr), 1720 and 1604 (br) cm-1.
The synthetic route of 24228-40-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Hinks; Jeremy David; Takle; Andrew Kenneth; Hunt; Eric; US6020368; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem