Takata, T; Hirano, K; Miura, M in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan published Synthesis of alpha-Trifluoromethylamines by Cu-Catalyzed Regio- and Enantioselective Hydroamination of 1-Trifluoromethylaikenes in 2019, Cited 81. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.
A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.
About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or concate me.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane
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