With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-40-6,4,4-Dimethylpiperidine-2,6-dione,as a common compound, the synthetic route is as follows.
Crude 2- (2-METHOXY-5-NITRO-PHENOXY)-ETHANOL (0.43 g, 2 MMOL) was dissolved in dry THF, 4, 4-dimethylglutarimide (0.28 g, 2 mmol), triphenylphosphine (0.52 g, 2 MMOL) and diethylazodicarboxylate (1.1 ml, 2.4 MMOL) were added at 45 C. After 6 h the reaction mixture was concentrated in vacuo and purified by flash-chromatography (cyclohexane/ ethyl ether 3/7) to give 0.41 g of the title compound as a white solid. NMR (‘H, CECI3) : 8 7.88 (d, 1H), 7.73 (s, 1H), 6.85 (d, 1H), 4.30-4. 15 (m, 4H), 3.90 (s, 3H), 2.52 (s, 4H), 1.13 (s, 6H)., 1123-40-6
As the paragraph descriping shows that 1123-40-6 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/89897; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem