41373-39-1,41373-39-1, (S)-Piperidin-2-ylmethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 4-((6-ethoxy-6-oxohexyl)oxy)-5-methoxy-2-nitrobenzoic acid (16 ) (2.00 g, 5.60 mmol) in dichloromethane (40 mL) was charged with trimethyl amine (4.70 mL, 33.8 mmol) and 0-(7-azabenzotriazole-i-yl)-A V,A V-tetramethyluronium hexafluoro- phosphate (2.20 g, 5.90 mmol) and the resulting mixture was stirred for 2 h at room temperature. A solution of (S,)-piperidin-2-ylmethanol (647 mg, 5.63 mmol) in dichloromethane (10 mL) was then added and the resulting mixture was stirred for 16 h at room temperature. The reaction was quenched with a saturated aqueous solution of sodium hydrogen carbonate (40 mL), the phases were separated and the aqueous layer was further extracted with dichloromethane (20 mL). The combined organic extracts were washed with brine (40 mL), dried over magnesium sulfate, filtered and (1451) concentrated to give an amber oil. Purification was carried out by column (1452) chromatography (silica), eluting with ethyl acetate/ hexane (from 0percent to 100percent), to give the title compound (1.20 g, 48percent) as a colourless oil. (1453) NMR (400 MHz, CDCI3) delta 7.63-7.6o (m, iH), 6.77-6.75 (m, iH), 4.13-4.02 (m, 4H), 3-93 (s, 3H), 3-78-3-70 (m, iH), 3-68-3-39 (m, iH), 3-i8-3-H (m, 3H), 2.32 (t, J=7-6 Hz, 2H), 1.91-1.83 (m, 2H), 1.72-1.39 (m, 11H), 1.26 (t, J=7-i Hz, 3H); MS M/Z (EIMS) = 453 (M+H)+; LCMS (Method B): tR = 3.63 min.
The synthetic route of 41373-39-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (243 pag.)WO2017/194960; (2017); A1;,
Piperidine – Wikipedia
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