With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21987-29-1,4,4-Difluoropiperidine,as a common compound, the synthetic route is as follows.
Example 1683-(4-Cyclohexylamino-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-(4,4-drfluoro-piperidin-1-yl)-propan-1-oneTo a solution of Intermediate 23 (35 mg, 0.12 mmol) in DMF (1.5 ml) was added HATU (48 mg, 0.13 mmol) and Lambda/,Lambda/-diisopropylethylamine (126 mul, 0.73 mmol). 4,4-difluoro0 piperidine (19 mul, 0.18 mmol) was then added and the resulting solution was left to stir at room temperature overnight. The volatiles were removed under reduced pressure and the crude product was re-dissolved in 10percent MeOH/DCM and eluted though an Isolute-NH2 cartridge. The crude product purified by flash chromatography eluting with 10percent MeOH/DCM to give a yellow gum (28 mg, 61percent). 1H NMR (400 MHz, DMSO-Cf6) delta ppm-5 1.14 – 1.26 (m, 1 H), 1.30 – 1.46 (m, 4 H), 1.60 – 1.72 (m, 1 H), 1.71 – 2.01 (m, 8 H), 2.87 (t, 2 H), 3.21 (t, J=6.4 Hz, 2 H), 3.49 – 3.60 (m, 4 H), 4.01 (br. s., 1 H), 6.67 (br. s., 1 H), 7.62 (d, J=6.0 Hz, 1 H); m/z (ES+APCl)+: 392 [M + H]+., 21987-29-1
As the paragraph descriping shows that 21987-29-1 is playing an increasingly important role.
Reference£º
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; SMILJANIC, Ela; HARDING, Denise, Jamilla; HOUGH, Joanne; WO2010/106333; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem