In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 99780-98-0, name is tert-Butyl (2-oxopiperidin-3-yl)carbamate, introducing its new discovery. SDS of cas: 99780-98-0
A series of inhibitors of angiotensin converting enzyme (ACE, dipeptidyl carboxypeptidase, EC 3.4.15.1) is described which addresses certain conformational aspects of the enzyme-inhibitor interaction.In this study the alanylproline portion of the potent ACE inhibitor enalaprilat (2) is replaced by a series of monocyclic lactams containing the required recognition and binding elements.In order to more fully assess the lactam ring conformations and the key backbone angle psi as defined in 3 with respect to possible enzyme-bound conformations, a series of model lactams was investigated with use of molecular mechanics.The results point to a correlation between inhibitor potency (IC50) and the computed psi angle for the lowest energy conformation of the model compounds.Thus the psi angle as defined in 3 is an important determinant in the binding of inhibitors to ACE.The inhibition data in conjuction with the computational data have served to define a window of psi angles from 130 deg to 170 deg which seems to be acceptable to the ACE active site.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 99780-98-0 is helpful to your research. SDS of cas: 99780-98-0
Reference：
Piperidine – Wikipedia,
Piperidine | C5H16653N – PubChem