With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22065-85-6,1-Benzylpiperidine-4-carbaldehyde,as a common compound, the synthetic route is as follows.
To a cooled solution of 1-benzyl-4-piperidinecarboxaldehyde (407 mg, 2.0 mmol) and propargylamine (165 mg, 3.0 mmol) in MeOH (6 mL) at 0 C, a small amount of CF3CO2H (5 drops) was added. After being stirred for 1 h, NaBH3CN (189 mg, 2.9 mmol) was added to the solution portionwsise. The mixture was stirred at rt overnight and then quenched with aqueous saturated NaHCO3. The mixture was concentrated in vacuo and then extracted with AcOEt.
The synthetic route of 22065-85-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Universitat Autonoma de Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); National University Corporation Okayama University; Universidad de Alcala; Esteban, Gerard; Unzeta, Mercedes; Inokuchi, Tsutomu; Marco-Contelles, Jose Luis; Samadi, Abdelouahid; Iriepa, Isabel; Ojima, Masaki; Li, Wang; EP2727916; (2014); A1;,
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