Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Safety of tert-Butyl 4-formylpiperidine-1-carboxylate, Which mentioned a new discovery about 137076-22-3
During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2. A key challenge in this program was the poor physicochemical properties of the initial lead compound 5. Integration of structure-based drug design and physical properties-based design resulted in replacement of a highly hydrophobic poly fluorinated aryl ring by a simple trifluoromethyl that led to identification of compound 6 with much improved physicochemical properties. Subsequent SAR studies led to the synthesis of new pyran analog 7 with improved cell potency. Further optimization of pharmacokintetics properties by increasing permeability with appropriate fluorinated alkyl led to compound 8 as a potent, selective AKT inhibitors that blocks the phosphorylation of GSK3beta in vivo and had robust, dose and concentration dependent efficacy in the U87MG tumor xenograft model.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Safety of tert-Butyl 4-formylpiperidine-1-carboxylate, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 137076-22-3
Reference：
Piperidine – Wikipedia,
Piperidine | C5H16369N – PubChem