Electric Literature of 158407-04-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 158407-04-6, Name is tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate, molecular formula is C11H20BrNO2. In a Article，once mentioned of 158407-04-6
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monotherapy for the treatment of tumors with activated AKT. Herein, we describe our lead optimization studies culminating in the discovery of compound 3g (GSK690693). Compound 3g is a novel ATP competitive, pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively. An X-ray cocrystal structure was solved with 3g and the kinase domain of AKT2, confirming that 3g bound in the ATP binding pocket. Compound 3g potently inhibits intracellular AKT activity as measured by the inhibition of the phosphorylation levels of GSK3beta. Intraperitoneal administration of 3g in immunocompromised mice results in the inhibition of GSK3beta phosphorylation and tumor growth in human breast carcinoma (BT474) xenografts.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 158407-04-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 158407-04-6, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H22529N – PubChem