With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.169457-73-2,tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
133a) tert-butyl 4-(2-((2Z)-2-(methylimino)-1,3-thiazol-3(2H)-yl)ethyl)-1-piperidinecarboxylate To a solution of tert-butyl 4-(2-bromoethyl)-1-piperidinecarboxylate (D. Brundish et al., J. Med. Chem., 42, 4584 (1999); 5.0 g) and 2-methylaminothiazole (O. Kemal et al., J. Chem. Soc. Perkin I, 5, 1569 (1981); 3.9 g) in DMF (50 ml) was added potassium iodide (5.7 g), and mixed at 80C for 12 hours. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in chloroform and a saturated aqueous potassium hydrogen carbonate solution. The organic layer was collected by separation, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with silica gel column to obtain the title compound as a brown oil (1.25 g, 22%). NMR (CDCl3) delta: 1.06-1.21 (2H, m), 1.45 (9H, s), 1.47 (1H, m), 1.58-1.69 (4H, m), 2.59-2.74 (2H, m), 2.97 (3H, s), 3.75 (2H, t, J=7.4), 4.00-4.16 (2H, br), 5.90 (1H, d, J=4.9), 6.51 (1H, d, J=4.9).
169457-73-2 tert-Butyl 4-(2-bromoethyl)piperidine-1-carboxylate 10541625, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1695961; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem